Les défis de la mesure du glucose
Dr. David Grenache témoigne
- Date de sortie: 03.03.2025
- Durée: 23 minutes
- Invité: Dr. David Grenache
- Hôte: Director Global Medical & Clinical Affairs Ana-Maria Šimundić
- Introduction: Le Dr David Grenache, aujourd'hui à la retraite, ancien Directeur Scientifique de TriCore Reference Labs à Alberquerque, au Nouveau Mexique, partage son point de vue sur les méthodes de stabilisation du glucose avec notre animatrice Ana-Maria Šimundić.
Chronologie de l'épisode 2
- 00:17 - Présentation de David Grenache
- 02:55 - La difficulté de l'analyse du glucose réside dans le fait qu'il diminue rapidement s'il ne peut pas être traité immédiatement ou stabilisé de manière appropriée
- 04:13 - Comment les laboratoires tentent de stabiliser le glucose et pourquoi ces méthodes ne sont pas parfaites
- 05:56 - Que fait le tube VACUETTE® FC Mix de Greiner Bio-One?
- 08:28 - Comment les échantillons sont-ils traités au laboratoire TriCore?
- 10:08 - Qu'en est-il du traitement des échantillons qui ont dû être transportés sur de longues distances?
- 11:32 - Limites de décision (seuils) pour le diagnostic du diabète sucré
- 18:22 - Faut-il normaliser les tests de glycémie ? Existe-t-il des lignes directrices ?
- 20:00 - Quel est le potentiel des tubes citrate en dehors du glucose?
Principaux sujets
Stabilizing glucose has a great impact on diagnoses rates of diabetes
- Glucose declines rapidly in whole blood - at a rate of 7-8% per hour - so preventing this decline is important for accurate diagnosis of diabetes mellitus
Some stabilization methods are imperfect or impractical
- Sodium fluoride is a commonly used stabilizer, but whilst it inhibits enolase in the glycolytic pathway, other enzymes remain active and continue to metabolize glucose
Using a VACUETTE® FC Mix tube does the job
- FC Mix tubes contain fluoride to inhibit enolase, citric acid to acidify the sample and inhibit other glycolytic enzymes, as well as EDTA that chelates the magnesium.
“VACUETTE® FC Mix tubes contain citric acid in addition to fluoride, enable acidification of the sample and inhibit other glycolytic enzyzmes. Additionally, EDTA chelates the magnesium, a cofactor for enzyzme activity.”
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Assiamira Ferrara, Monique M. Hedderson, Charles P. Quesenberry, Joseph V. Selby; Prevalence of Gestational Diabetes Mellitus Detected by the National Diabetes Data Group or the Carpenter and Coustan Plasma Glucose Thresholds. Diabetes Care 1 September 2002; 25 (9): 1625–1630. doi.org/10.2337/diacare.25.9.1625
diabetesjournals.org/care/article/25/9/1625/21728/Prevalence-of-Gestational-Diabetes-Mellitus
